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33)34)29(20-6-9-27-28(16-20)43-13-12-42-27)44-25-7-8-26-22(15-25)17-35-38(26)24-5-3-4-21(14-24)30(39)37-23-10-11-41-18-23/h3-9
O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays
Small molecule modulation of Smoothened activity
15(10):3368-72
Liarozole Size:Contact [email protected] for quotation 33)34)29(20-6-9-27-28(16-20)43-13-12-42-27)44-25-7-8-26-22(15-25)17-35-38(26)24-5-3-4-21(14-24)30(39)37-23-10-11-41-18-23/h3-9Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism blocking agent (RAMBA). Liarozole inhibits the cytochrome P450 (CYP26) dependent 4 hydroxylation of retinoic acid (IC50=7 M), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties. Product information CAS Number: 115575 11 6 Molecular Weight: 308. 76 Formula: C17H13ClN4 Chemical Name: 6 [(3 chlorophenyl)(1H