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InChiKey: DQIJBACZLYDYMW-SRQPLJGDSA-N
37 the effects of a class iii histone deacetylase inhibitor (sirtinol) on early development of porcine cloned embryos
including AKT
Kordulakova J
OSU-T315 - CAS# 2070015-22-2 Size:10mg solid InChiKey: DQIJBACZLYDYMW-SRQPLJGDSA-NOSU T315 (ILK IN 1) is a small Integrin linked kinase (ILK) inhibitor with an IC50 of 0. 6 M, inhibiting PI3K AKT signaling by dephosphorylation of AKT Ser473 and other ILK targets (GSK 3 and myosin light chain). OSU T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase dependent apoptosis in an ILK independent manner[2]. OSU T315 causes cell death through apoptosis and autophagy. Product information CAS
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